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Calibration of an instrument is the process of determining its accuracy. The process involves obtaining a reading from the instrument and measuring its variation from the reading obtained from a standard instrument. Calibration of an instrument also involves adjusting its precision and accuracy so that its readings come in accordance with the established standard.

Validation comprehensively establishes in a documented way the instrument is working accurately. A validation process offers evidence that the components critically contributing to accurate functioning of the equipment consistently meet the predefined specifications and operational attributes. The process involves keenly identifying and quantifying each constituting element produced during measurements.